All this coverage in just one monthly chewable

Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against:

Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable—for protection against:

  • Check-iconHeartworm disease
  • Check-iconTicks* & fleas
  • Check-iconRoundworms & hookworms
  • Check-iconInfections that may cause Lyme disease by killing deer ticks
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*Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, Rhipicephalus sanguineus.

Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria stenocephala.

Simparica Trio is designed for defense

Just one Simparica Trio does the job of two or three parasiticides in a single chewable—the way pet owners prefer to give preventatives to their dogs.1

Just one Simparica Trio does the job of two or three parasiticides in a single chewable—the way pet owners prefer to give preventatives to their dogs.1

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Demonstrated safe for dogs

Approved for puppies as young as 8 weeks, weighing 2.8 lbs or more

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Highly palatable2 liver-flavored chewable

Can be given with or without food. Consumed by free choice or with food 91.9% of the time

Can be given with or without food. Consumed by free choice or with food 91.9% of the time

See the Simparica Trio difference

Compare the labels of other products with Simparica Trio

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SLIDE TO COMPARE

*Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhipicephalus sanguineus.

Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum, and Rhipicephalus sanguineus.

Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum, Rhipicephalus sanguineus, and Haemaphysalis longicornis.

§Ixodes scapularis, Dermacentor variabilis, Rhipicephalus sanguineus, and Haemaphysalis longicornis for 12 weeks. Bravecto is not effective against Amblyomma americanum beyond 8 weeks after dosing.

#Simparica Trio starts killing deer ticks within 8 hours and starts killing fleas within 4 hours.

**For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina).

††For the treatment of hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.

‡‡ProHeart 12 larval and adult stages of Ancylostoma caninum and Uncinaria stenocephala.

§§As a direct result of killing deer ticks.

NexGard and Heartgard are registered trademarks of Boehringer Ingelheim Animal Health USA Inc. Bravecto is a registered trademark of Intervet Inc. d/b/a Merck Animal Health. Credelio and Interceptor are registered trademarks of Elanco or its affiliates.

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Studies to support FDA approval showed that 1 dose of Simparica Trio provided 100% protection against heartworm disease

Studies to support FDA approval showed that 1 dose of Simparica Trio provided 100% protection against heartworm disease

Heartworm disease is a year-round threat that has been diagnosed in all 50 states. Clinics reported a 21% increase in heartworm positive cases in a 3 year period.8

Heartworm disease is a year-round threat that has been diagnosed in all 50 states. Clinics reported a 21% increase in heartworm positive cases in a 3 year period.8


Infection is widespread across the US

Infection is widespread across the US

as shown by sales of 1 heartworm treatment9

Map based on 2018 Diroban® (melarsomine dihydrochloride) sales.

as shown by sales of 1 heartworm treatment9

Map based on 2018 Diroban® (melarsomine dihydrochloride) sales.

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Just one Simparica Trio chewable delivered fully effective heartworm disease protection

In two well-controlled studies, a single oral dose of Simparica Trio was 100% effective in preventing the development of heartworm disease in dogs inoculated with infective larvae 30 days before treatment
Heartworm-one-month-dose-dog

Just one Simparica Trio chewable delivered fully effective heartworm disease protection

In two well-controlled studies, a single oral dose of Simparica Trio was 100% effective in preventing the development of heartworm disease in dogs inoculated with infective larvae 30 days before treatment
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white-IconSimparica Trio was designed to balance optimal effectiveness with safety to prevent heartworm disease

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Keep dogs protected from ticks and fleas

It only takes one infected tick to spread disease. Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease, and are active throughout the year.10

Flea infestations may take several months to resolve, are frustrating, and can be costly. Flea allergy dermatitis can result in symptoms for dogs.*

It only takes one infected tick to spread disease. Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease, and are active throughout the year.10

Flea infestations may take several months to resolve, are frustrating, and can be costly. Flea allergy dermatitis can result in symptoms for dogs.*

*Symptoms can include erythema, papules, scaling, alopecia, dermatitis/pyodermatitis, and pruritus.


Your recommendation matters

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Simparica Trio is proven to kill 5 species of ticks

  • Check-iconFDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks
  • Check-iconDemonstrated ≥98.9% effectiveness against existing tick infestations in 48 hours†‡
  • Check-iconEffective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis11
ticks ticks ticks

Simparica Trio protects against fleas

Simparica Trio protects against fleas

  • Check-iconStarts killing fleas within 4 hours
  • Check-iconAchieved 100% efficacy 8 hours after treatment in a study
  • Check-iconSubstantially improved the clinical signs of flea allergy dermatitis
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In well-controlled laboratory studies.
Against Amblyomma americanum, Simparica Trio was 99.4% effective 72 hours after treatment of existing infestations.

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Treatment and control of roundworms and hookworms

Treatment and control of roundworms and hookworms

Treat and control intestinal parasites to protect dogs. Contaminated environments put pets and people at risk.

Just one Simparica Trio chewable offers protection from roundworms and hookworms
Just one Simparica Trio chewable offers protection from roundworms and hookworms
  • Pyrantel protects against intestinal parasites
  • In clinical studies, Simparica Trio was 99.2% effective for adult roundworm and reduction in fecal egg count12*
  • Demonstrated >94% efficacy for hookworm, in studies13†

*Also effective against immature adult stage of T. canis.9

For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.

Simparica Trio rewards

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FOR YOUR PRACTICE

My Zoetis Rewards

Sign up for savings when you purchase Simparica Trio for your practice.

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FOR PET OWNERS

Zoetis Petcare Rewards

Help dog owners save by earning rewards when they purchase Simparica Trio.

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Clinic & staff resources

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Benefits of protection

View the benefits of Simparica Trio in this quick video.

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Implementation video

See 3 simple steps to making Simparica Trio an easy choice for your clinic.

Pet owner resources

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Waiting room video

Share the benefits of Simparica Trio with your clients.

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In-clinic flyer

Use this in your waiting room or exam room to inform clients.

Learn more about Simparica Trio

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Product Details

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The Simparica Trio Guarantee

References

  1. Foster Rosenblatt US Quantitative Research Findings Final Report. Data on file. Zoetis Inc. 
  2. Study A161C-US-15-634. Data on file. Zoetis Inc.
  3. NexGard® PLUS [package insert]. Duluth, GA: Boehringer Ingelheim Group; 2023.
  4. NexGard® [package insert]. Duluth, GA: Boehringer Ingelheim Group; 2023.
  5. Heartgard® Plus [package insert]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc; 2019.
  6. Bravecto® package insert]. Summit, NJ: Merck & Co; 2023.
  7. Interceptor® Plus [package insert]. Greenfield, IN: Elanco; 2020.
  8. Drake J, Wiseman S. Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013–2016. Parasit Vectors. 2018;11(1):39.
  9. Study A166-US-17-821. Data on file. Zoetis Inc.
  10. Blagburn BL, Dryden MW. Biology, treatment, and control of tick infestations. Vet Clin North Am Small Anim Pract. 2009;39(6):1173-2000. 
  11. Companion Animal Parasite Council. Ticks. April 12, 2017. https://capcvet.org/guidelines/ticks. Accessed March 17, 2023.
  12. Study A161C-US-15-530. Data on file. Zoetis Inc. 
  13. Nemex-2 Suspension Approved Package Insert, Kalamazoo, MI: Zoetis Inc; 2019.

STR-00060R4

IMPORTANT SAFETY INFORMATION: 

See Full Prescribing Information. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

IMPORTANT SAFETY INFORMATION: 

See Full Prescribing Information. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.